On September 16, 2024, Professor Christoph Kosinski, chief of neurology at Rhein-Maas-Kliniken, delivered a great lecture on “Stroke Workup and Etiology”. We are excited that more than 30 participants where eager to explore the causes of stroke and how to prevent future stroke events.

Dr. Kosinski began the lecture with a critical question: “Why put a patient in a stroke unit?”. Dr. Kosinski highlighted that stroke units significantly improve patient outcomes and prevent death. He emphasized that stroke units focus on three critical components: Early rehabilitation, prevention of complications and prevention of recurrent stroke. These three pillars form the backbone of effective stroke care, optimizing patient recovery and reducing the risk of further strokes.

Understanding the underlying cause of a stroke is essential for determining the most

appropriate treatment and preventive measures. Dr. Kosinski introduced the TOAST

classification, a system that categorizes stroke etiologies into five distinct groups:

1. Macroangiopathy: stenosis of intracranial or extracranial arteries due to

atherosclerosis. Diagnosis is typically done through duplex sonography. Secondary

prevention strategies include lifestyle changes, medications and vascular surgery.

2. Cardioembolism: Common in atrial fibrillation and managed with anticoagulants.

3. Small Vessel Disease: Tthickening of capillary walls due to atherosclerosis, amyloid

plaques, or inherited diseases. Prevention through reduction of risk factors.

4. Other Determined Etiologies: Includes rare causes like vasculitis, moya-moya

disease, thrombophilia or carotid dissection.

5. Undetermined Etiology: Strokes with unclear or multiple causes.

The causes of stroke can vary significantly based on the patient’s age. Patients over 50

often suffer from atrial fibrillation, atherosclerosis or microangiopathy, while in younger

patients rare causes like dissection or patent foramen ovale are more frequent. This

means that different diagnostic tools become more relevant depending on the patient in

front of you. However, the two most important diagnostic tools in stroke etiology are ECG

and duplex sonography. Dr. Kosinski also recommended the use of checklists to ensure

that all aspects of stroke identification and treatment are considered.

Prevention is a cornerstone of stroke management, and Dr. Kosinski stressed the

importance of secondary prevention measures. Secondary prevention includes vascular

surgery for carotid stenosis and oral anticoagulation for atrial fibrillation, along with

lifestyle modifications like managing blood pressure and quitting smoking.

The session concluded with a lively discussion on stroke treatment strategies in Nepal.

Additionally, many participants had insightful questions, enriching the overall learning

experience for everyone involved. We extend our thanks to Dr. Christoph Kosinski and all

participants for another fantastic lecture.

Mark your calendars for the next lecture on September 26, 2024, where Dr. Pradesh

Ghimire will cover “Introduction to Neuroimaging for Acute Stroke.”

Plese send me the free “Stroke Knowledge” materials: